Single-Use Centrifuges - Optimize Product Recovery and Scalability
Advanced Therapies benefit from systems that minimize contamination risks to the product as well as to the environment, enable high product recovery and fast processing times. The UniFuge® system address those needs. The UniFuge is ideal for delicate cultures, such as lentiviruses, and replaces filtration during primary recovery, eliminating the issue of filter clogging and HCP going to downstream purification.
Advanced Therapy Case Studies
Lentiviral vectors are commonly used in the production of ex vivo cell therapies to transduce various cell types. Lentiviral vectors are sensitive to the shear forces of traditional continuous centrifugation systems. Additionally, significant yield losses due to adsorption effects can be seen during the primary clarification of lentiviral vectors with single-use filtration methods such as depth filtration.
Depth filtration has become a trusted standby for scientists and engineers looking to separate viral vectors – a popular delivery system for gene-based therapies and vaccines – from the HEK293 cell culture in which they’re typically grown. In this case study, we show how the UFMini single-use centrifuge significantly reduces filtration needs and drastically enhances the amount of viral titer collected when compared to conventional methods.
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Advantages of Single-Use Centrifuges for C&G
Easy-to-use, reliable equipment that delivers high product recovery.
Performance
Our proven low-shear technology boasts up to 98% yield and 98% or higher typical cell viability.
Scalability
Our equipment can be used from development to commercial licensure and across different reactor volumes.
Ease of Use
Our machines are rapid to install and simple to operate.
Small Footprint
Our single-use centrifuges have a small footprint.